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Thrift, A.P.* ; Gong, J.* ; Peters, U.* ; Chang-Claude, J.* ; Rudolph, A.* ; Slattery, M.L.* ; Chan, A.T.* ; Esko, T.* ; Wood, A.R.* ; Yang, J.* ; Vedantam, S.* ; Gustafsson, S.* ; Pers, T.H.* ; GIANT Consortium (Albrecht, E. ; Gieger, C. ; Grallert, H. ; Heid, I.M. ; Illig, T. ; Müller-Nurasyid, M. ; Peters, A. ; Thorand, B. ; Wichmann, H.-E.) ; Baron, J.A.* ; Bézieau, S.* ; Kuery, S.* ; Ogino, S.* ; Berndt, S.I.* ; Casey, G.* ; Haile, R.W.* ; Du, M.* ; Harrison, T.A.* ; Thornquist, M.* ; Duggan, D.J.* ; Le Marchand, L.* ; Lemire, M.* ; Lindor, N.M.* ; Seminara, D.* ; Song, M.* ; Thibodeau, S.N.* ; Cotterchio, M.* ; Win, A.K.* ; Jenkins, M.A.* ; Hopper, J.L.* ; Ulrich, C.M.* ; Potter, J.D.* ; Newcomb, P.A.* ; Schoen, R.E.* ; Hoffmeister, M.* ; Brenner, H.* ; White, E.S.* ; Hsu, L.A.* ; Campbell, P.T.*

Mendelian randomization study of height and risk of colorectal cancer.

Int. J. Epidemiol. 44, 662-672 (2015)
Verlagsversion DOI
Free by publisher
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Background: For men and women, taller height is associated with increased risk of all cancers combined. For colorectal cancer (CRC), it is unclear whether the differential association of height by sex is real or is due to confounding or bias inherent in observational studies. We performed a Mendelian randomization study to examine the association between height and CRC risk. Methods: To minimize confounding and bias, we derived a weighted genetic risk score predicting height (using 696 genetic variants associated with height) in 10 226 CRC cases and 10 286 controls. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (95% CI) for associations between height, genetically predicted height and CRC. Results: Using conventional methods, increased height (per 10-cm increment) was associated with increased CRC risk (OR = 1.08, 95% CI = 1.02-1.15). In sex-specific analyses, height was associated with CRC risk for women (OR = 1.15, 95% CI = 1.05-1.26), but not men (OR = 0.98, 95% CI = 0.92-1.05). Consistent with these results, carrying greater numbers of (weighted) height-increasing alleles (per 1-unit increase) was associated with higher CRC risk for women and men combined (OR = 1.07, 95% CI = 1.01-1.14) and for women (OR = 1.09, 95% CI = 1.01-1.19). There was weaker evidence of an association for men (OR = 1.05, 95% CI = 0.96-1.15). Conclusion: We provide evidence for a causal association between height and CRC for women. The CRC-height association for men remains unclear and warrants further investigation in other large studies.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Body Height ; Colorectal Cancer ; Epidemiology; Genome-wide Association; Colon-cancer; Body-size; United-states; Instrumental Variables; Genetic Epidemiology; Susceptibility Loci; Cigarette-smoking; Rectal-cancer; Women
ISSN (print) / ISBN 0300-5771
e-ISSN 1464-3685
Quellenangaben Band: 44, Heft: 2, Seiten: 662-672 Artikelnummer: , Supplement: ,
Verlag Oxford University Press
Verlagsort Oxford
Begutachtungsstatus Peer reviewed