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Kirscher, L.* ; Dean-Ben, X.L. ; Scadeng, M.* ; Zaremba, A. ; Zhang, Q.* ; Kober, C.* ; Fehm, T.F.* ; Razansky, D. ; Ntziachristos, V. ; Stritzker, J.* ; Szalay, A.A.*

Doxycycline inducible melanogenic vaccinia virus as theranostic anti-cancer agent.

Theranostics 5, 1045-1057 (2015)
Verlagsversion Anhang DOI
Open Access Gold
Creative Commons Lizenzvertrag
We reported earlier the diagnostic potential of a melanogenic vaccinia virus based system in magnetic resonance (MRI) and optoacoustic deep tissue imaging (MSOT). Since melanin overproduction lead to attenuated virus replication, we constructed a novel recombinant vaccinia virus strain (rVACV), GLV-1h462, which expressed the key enzyme of melanogenesis (tyrosinase) under the control of an inducible promoter-system. In this study melanin production was detected after exogenous addition of doxycycline in two different tumor xenograft mouse models. Furthermore, it was confirmed that this novel vaccinia virus strain still facilitated signal enhancement as detected by MRI and optoacoustic tomography. At the same time we demonstrated an enhanced oncolytic potential compared to the constitutively melanin synthesizing rVACV system.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Molecular Imaging ; Oncolysis ; Reporter Gene ; Virotherapy
e-ISSN 1838-7640
Zeitschrift Theranostics
Quellenangaben Band: 5, Heft: 10, Seiten: 1045-1057 Artikelnummer: , Supplement: ,
Verlag Ivyspring
Begutachtungsstatus Peer reviewed