PuSH - Publication Server of Helmholtz Zentrum München

Acid-coated textiles (pH 5.5-6.5) - a new therapeutic strategy for atopic eczema?

Acta Derm.-Venereol. 95, 659-663 (2015)
Publishers Version DOI
Open Access Gold
Creative Commons Lizenzvertrag
as soon as is submitted to ZB.
Increased transepidermal water loss (TEWL) and decreased skin capacitance are characteristic features of the disturbed epidermal barrier in atopic eczema (AE). The "acid mantle", which is a slightly acidic film on the surface of the skin has led to the development of acidic emollients for skin care. In this context, the effect of citric acid-coated textiles on atopic skin has not been examined to date. A textile carrier composed of cellulose fibres was coated with a citric acid surface layer by esterification, ensuring a constant pH of 5.5-6.5. Twenty patients with AE or atopic diathesis were enrolled in the study. In a double-blind, half-side experiment, patients had to wear these textiles for 12 h a day for 14 days. On day 0 (baseline), 7 and 14, tolerability (erythema, pruritus, eczema, wearing comfort) and efficacy on skin barrier were assessed by TEWL skin hydration (corneometry/ capacitance), pH and clinical scoring of eczema (SCO-RAD). Citric acid-coated textiles were well tolerated and improved eczema and objective parameters of skin physiology, including barrier function and a reduced skin surface pH, with potential lower pathogenic microbial colonisation.
Altmetric
Additional Metrics?
Edit extra informations Login
Publication type Article: Journal article
Document type Scientific Article
Keywords Atopic Eczema ; Acid-coated Textiles ; Transepidermal Water Loss (tewl) ; Skin Capacitance; Citric-acid; Water-loss; Dermatitis; Filaggrin; Barrier; Functionality; Children; Efficacy; Safety
Reviewing status