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Exploration of energy metabolism in the mouse using indirect calorimetry: Measurement of Daily Energy Expenditure (DEE) and Basal Metabolic Rate (BMR).

Curr. Protoc. Mouse Biol. 5, 205-222 (2015)
Current comprehensive mouse metabolic phenotyping involves studying energy balance in cohorts of mice via indirect calorimetry, which determines heat release from changes in respiratory air composition. Here, we describe the measurement of daily energy expenditure (DEE) and basal metabolic rate (BMR) in mice. These well-defined metabolic descriptors serve as meaningful first-line read-outs for metabolic phenotyping and should be reported when exploring energy expenditure in mice. For further guidance, the issue of appropriate sample sizes and the frequency of sampling of metabolic measurements is also discussed.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Basal Metabolic Rate ; Daily Energy Expenditure ; Indirect Calorimetry ; Mouse Phenotyping
ISSN (print) / ISBN 2161-2617
Quellenangaben Volume: 5, Issue: 3, Pages: 205-222 Article Number: , Supplement: ,
Publisher Wiley
Reviewing status Peer reviewed