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Bluher, A.* ; Devan, W.J.* ; Holliday, E.G.* ; Nalls, M.* ; Parolo, S.* ; Bione, S.* ; Giese, A.K.* ; Boncoraglio, G.B.* ; Maguire, J.M.* ; Müller-Nurasyid, M. ; Gieger, C. ; Meschia, J.F.* ; Rosand, J.* ; Rolfs, A.* ; Kittner, S.J.* ; Mitchell, B.D.* ; O'Connell, J.R.* ; Cheng, Y.C.*

Heritability of young- and old-onset ischaemic stroke.

Eur. J. Neurol. 22, 1488-1491 (2015)
Open Access Green as soon as Postprint is submitted to ZB.
BACKGROUND AND PURPOSE: Although the genetic contribution to stroke risk is well known, it remains unclear if young-onset stroke has a stronger genetic contribution than old-onset stroke. This study aims to compare the heritability of ischaemic stroke risk between young and old, using common genetic variants from whole-genome array data in population-based samples. METHODS: This analysis included 4050 ischaemic stroke cases and 5765 controls from six study populations of European ancestry; 47% of cases were young-onset stroke (age < 55 years). To quantify the heritability for stroke risk in these unrelated individuals, the pairwise genetic relatedness was estimated between individuals based on their whole-genome array data using a mixed linear model. Heritability was estimated separately for young-onset stroke and old-onset stroke (age ≥ 55 years). RESULTS: Heritabilities for young-onset stroke and old-onset stroke were estimated at 42% (±8%, P < 0.001) and 34% (±10%, P < 0.001), respectively. CONCLUSIONS: Our data suggest that the genetic contribution to the risk of stroke may be higher in young-onset ischaemic stroke, although the difference was not statistically significant.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Heritability ; Ischemic Stroke ; Stroke
ISSN (print) / ISBN 1351-5101
e-ISSN 1468-1331
Quellenangaben Volume: 22, Issue: 11, Pages: 1488-1491 Article Number: , Supplement: ,
Publisher Wiley
Reviewing status Peer reviewed