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Sekula, P.* ; Goek, O.N.* ; Quaye, L.* ; Barrios, C.* ; Levey, A.S.* ; Römisch-Margl, W. ; Menni, C.* ; Yet, I.* ; Gieger, C. ; Inker, L.A.* ; Adamski, J. ; Gronwald, W.* ; Illig, T. ; Dettmer, K.* ; Krumsiek, J. ; Oefner, P.J.* ; Valdes, A.M.* ; Meisinger, C. ; Coresh, J.* ; Spector, T.D.* ; Mohney, R.P.* ; Suhre, K. ; Kastenmüller, G. ; Köttgen, A.*

A metabolome-wide association study of kidney function and disease in the general population.

J. Am. Soc. Nephrol. 27, 1175-1188 (2016)
Verlagsversion DOI
Free by publisher
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Small molecules are extensively metabolized and cleared by the kidney. Changes in serum metabolite concentrations may result from impaired kidney function and can be used to estimate filtration (e.g., the established marker creatinine) or may precede and potentially contribute to CKD development. Here, we applied a nontargeted metabolomics approach using gas and liquid chromatography coupled to mass spectrometry to quantify 493 small molecules in human serum. The associations of these molecules with GFR estimated on the basis of creatinine (eGFRcr) and cystatin C levels were assessed in ≤1735 participants in the KORA F4 study, followed by replication in 1164 individuals in the TwinsUK registry. After correction for multiple testing, 54 replicated metabolites significantly associated with eGFRcr, and six of these showed pairwise correlation (r≥0.50) with established kidney function measures: C-mannosyltryptophan, pseudouridine, N-acetylalanine, erythronate, myo-inositol, and N-acetylcarnosine. Higher C-mannosyltryptophan, pseudouridine, and O-sulfo-L-tyrosine concentrations associated with incident CKD (eGFRcr
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Ckd ; Epidemiology ; Gfr ; Metabolism ; Outcomes; Glomerular-filtration-rate; Protein C-mannosylation; Serum Creatinine; Transaldolase Deficiency; Uremic Patients; Renal-function; Genome-wide; Cystatin C; Pseudouridine; Accumulation
ISSN (print) / ISBN 1046-6673
e-ISSN 1533-3450
Quellenangaben Band: 27, Heft: 4, Seiten: 1175-1188 Artikelnummer: , Supplement: ,
Verlag American Society of Nephrology
Verlagsort Washington
Begutachtungsstatus Peer reviewed