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Insel, R.A.* ; Dunne, J.L.* ; Atkinson, M.A.* ; Chiang, J.L.* ; Dabelea, D.* ; Gottlieb, P.A.* ; Greenbaum, C.J.* ; Herold, K.C.* ; Krischer, J.P.* ; Lernmark, A.* ; Ratner, R.E.* ; Rewers, M.J.* ; Schatz, D.A.* ; Skyler, J.S.* ; Sosenko, J.M.* ; Ziegler, A.-G.

Staging presymptomatic type 1 diabetes: A scientific statement of JDRF, the Endocrine Society, and the American Diabetes Association.

Diabetes Care 38, 1964-1974 (2015)
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Insights from prospective, longitudinal studies of individuals at risk for developing type 1 diabetes have demonstrated that the disease is a continuum that progresses sequentially at variable but predictable rates through distinct identifiable stages prior to the onset of symptoms. Stage 1 is defined as the presence of β-cell autoimmunity as evidenced by the presence of two or more islet autoantibodies with normoglycemia and is presymptomatic, stage 2 as the presence of β-cell autoimmunity with dysglycemia and is presymptomatic, and stage 3 as onset of symptomatic disease. Adoption of this staging classification provides a standardized taxonomy for type 1 diabetes and will aid the development of therapies and the design of clinical trials to prevent symptomatic disease, promote precision medicine, and provide a framework for an optimized benefit/risk ratio that will impact regulatory approval, reimbursement, and adoption of interventions in the early stages of type 1 diabetes to prevent symptomatic disease.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
ISSN (print) / ISBN 0149-5992
e-ISSN 1935-5548
Zeitschrift Diabetes Care
Quellenangaben Band: 38, Heft: 10, Seiten: 1964-1974 Artikelnummer: , Supplement: ,
Verlag American Diabetes Association
Verlagsort Alexandria, Va.
Begutachtungsstatus Peer reviewed