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Giannopoulou, E.A.* ; Emmanouilidis, L. ; Sattler, M. ; Dodt, G.* ; Wilmanns, M.*

Towards the molecular mechanism of the integration of peroxisomal membrane proteins.

Biochim. Biophys. Acta-Mol. Cell Res. 1863, 863-869 (2016)
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The correct topogenesis of peroxisomal membrane proteins is a crucial step for the formation of functioning peroxisomes. Although this process has been widely studied, the exact mechanism with which it occurs has not yet been fully characterized. Nevertheless, it is generally accepted that peroxisomes employ three proteins - Pex3, Pex19 and Pex16 in mammals - for the insertion of peroxisomal membrane proteins into the peroxisomal membrane. Structural biology approaches have been utilized for the elucidation of the mechanistic questions of peroxisome biogenesis, mainly by providing information on the architecture of the proteins significant for this process. This review aims to summarize, compare and put into perspective the structural knowledge that has been generated mainly for Pex3 and Pex19 and their interaction partners in recent years.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Peroxisomal Membrane Proteins ; Peroxisome Biogenesis ; Pex19 ; Pex3 ; Structural Biology; Tail-anchored Proteins; Endoplasmic-reticulum; Saccharomyces-cerevisiae; Targeting Signals; Import Receptor; Mammalian Peroxisomes; Structural Basis; Matrix Proteins; Human Pex19p; Biogenesis
ISSN (print) / ISBN 0167-4889
e-ISSN 1879-2596
Quellenangaben Volume: 1863, Issue: 5, Pages: 863-869 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place Amsterdam
Reviewing status Peer reviewed