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de Vries, P.S.* ; Chasman, D.I.* ; Sabater-Lleal, M.* ; Chen, M.H.* ; Huffman, J.E.* ; Steri, M.* ; Tang, W.* ; Teumer, A.* ; Marioni, R.E.* ; Grossmann, V.* ; Hottenga, J.J.* ; Trompet, S.* ; Müller-Nurasyid, M. ; Zhao, J.H.* ; Brody, J.A.* ; Kleber, M.E.* ; Guo, X.* ; Wang, J.J.* ; Auer, P.L.* ; Attia, J.R.* ; Yanek, L.R.* ; Ahluwalia, T.S.* ; Lahti, J.* ; Venturini, C.* ; Tanaka, T.* ; Bielak, L.F.* ; Joshi, P.K.* ; Rocanin-Arjo, A.* ; Kolcic, I.* ; Navarro, P.* ; Rose, L.M.* ; Oldmeadow, C.* ; Riess, H. ; Mazur, J.* ; Basu, S.* ; Goel, A.* ; Yang, Q.* ; Ghanbari, M.* ; Willemsen, G.* ; Rumley, A.* ; Fiorillo, E.* ; de Craen, A.J.* ; Grotevendt, A.* ; Scott, R.A.* ; Taylor, K.D.* ; Delgado, G.E.* ; Yao, J.* ; Kifley, A.* ; Kooperberg, C.* ; Qayyum, R.* ; Lopez, L.M.* ; Berentzen, T.L.* ; Räikkönen, K.* ; Mangino, M.* ; Bandinelli, S.* ; Peyser, P.A.* ; Wild, S.* ; Tregouet, D.A.* ; Wright, A.F.* ; Marten, J.* ; Zemunik, T.* ; Morrison, A.C.* ; Sennblad, B.* ; Tofler, G.* ; de Maat, M.P.M.* ; de Geus, E.J.* ; Lowe, G.D.* ; Zoledziewska, M.* ; Sattar, N.* ; Binder, H.* ; Völker, U.* ; Waldenberger, M. ; Khaw, K.T.* ; McKnight, B.* ; Huang, J.* ; Jenny, N.S.* ; Holliday, E.G.* ; Qi, L.* ; McEvoy, M.G.* ; Becker, D.M.* ; Starr, J.M.* ; Sarin, A.P.* ; Hysi, P.G.* ; Hernandez, D.G.* ; Jhun, M.A.* ; Campbell, H.* ; Hamsten, A.* ; Rivadeneira, F.* ; McArdle, W.L.* ; Slagboom, P.E.* ; Zeller, T.* ; Koenig, W.* ; Psaty, B.M.* ; Haritunians, T.* ; Liu, J.* ; Palotie, A.* ; Uitterlinden, A.G.* ; Stott, D.J.* ; Hofman, A.* ; Franco, O.H.* ; Polasek, O.* ; Rudan, I.* ; Morange, P.E.* ; Wilson, J.F.* ; Kardia, S.L.* ; Ferrucci, L.* ; Spector, T.D.* ; Eriksson, J.G.* ; Hansen, T.* ; Deary, I.J.* ; Becker, L.C.* ; Scott, R.J.* ; Mitchell, P.* ; Marz, W.* ; Wareham, N.J.* ; Peters, A. ; Greinacher, A.* ; Wild, P.S.* ; Jukema, J.W.* ; Boomsma, D.I.* ; Hayward, C.* ; Cucca, F.* ; Tracy, R.* ; Watkins, H.* ; Reiner, A.P.* ; Folsom, A.R.* ; Ridker, P.M.* ; O'Donnell, C.J.* ; Smith, N.L.* ; Strachan, D.P.* ; Dehghan, A.*

A meta-analysis of 120,246 individuals identifies 18 new loci for fibrinogen concentration.

Hum. Mol. Genet. 25, 358-370 (2016)
Genome-wide association studies have previously identified 23 genetic loci associated with circulating fibrinogen concentration. These studies used HapMap imputation and did not examine the X chromosome. 1000 Genomes imputation provides better coverage of uncommon variants, and includes indels. We conducted a genome-wide association analysis of 34 studies imputed to the 1000 Genomes Project reference panel and including ∼120,000 participants of European ancestry (95,806 participants with data on the X chromosome). Approximately 10.7 million SNPs and 1.2 million indels were examined. We identified 41 genome-wide significant fibrinogen loci of which 18 were newly identified. There were no genome-wide significant signals on the X chromosome. The lead variants of 5 significant loci were indels. We further identified 6 additional independent signals, including 3 rare variants, at two previously characterized loci: FGB and IRF1. Together the 41 loci explain 3% of the variance in plasma fibrinogen concentration.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Genome-wide Association; C-reactive Protein; Cardiovascular-disease; Circulating Fibrinogen; Genetic Architecture; Variants; Design; Hemostasis; Resource; Health
ISSN (print) / ISBN 0964-6906
e-ISSN 1460-2083
Zeitschrift Human Molecular Genetics
Quellenangaben Band: 25, Heft: 2, Seiten: 358-370 Artikelnummer: , Supplement: ,
Verlag Oxford University Press ; HighWire Press
Verlagsort Oxford
Begutachtungsstatus