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A meta-analysis of 120,246 individuals identifies 18 new loci for fibrinogen concentration.
Hum. Mol. Genet. 25, 358-370 (2016)
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Genome-wide association studies have previously identified 23 genetic loci associated with circulating fibrinogen concentration. These studies used HapMap imputation and did not examine the X chromosome. 1000 Genomes imputation provides better coverage of uncommon variants, and includes indels. We conducted a genome-wide association analysis of 34 studies imputed to the 1000 Genomes Project reference panel and including ∼120,000 participants of European ancestry (95,806 participants with data on the X chromosome). Approximately 10.7 million SNPs and 1.2 million indels were examined. We identified 41 genome-wide significant fibrinogen loci of which 18 were newly identified. There were no genome-wide significant signals on the X chromosome. The lead variants of 5 significant loci were indels. We further identified 6 additional independent signals, including 3 rare variants, at two previously characterized loci: FGB and IRF1. Together the 41 loci explain 3% of the variance in plasma fibrinogen concentration.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Genome-wide Association; C-reactive Protein; Cardiovascular-disease; Circulating Fibrinogen; Genetic Architecture; Variants; Design; Hemostasis; Resource; Health
ISSN (print) / ISBN 0964-6906
Journal Human Molecular Genetics
Quellenangaben Volume: 25, Issue: 2, Pages: 358-370
Publisher Oxford University Press
Publishing Place Oxford
Reviewing status Peer reviewed