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Velroyen, A.* ; Yaroshenko, A.* ; Hahn, D.* ; Fehringer, A.* ; Tapfer, A.* ; Müller, M.* ; Noel, P.B.* ; Pauwels, B.* ; Sasov, A.* ; Yildirim, A.Ö. ; Eickelberg, O. ; Hellbach, K.* ; Auweter, S.D.* ; Meinel, F.G.* ; Reiser, M.F.* ; Bech, M.* ; Pfeiffer, F.*

Grating-based X-ray dark-field computed tomography of living mice.

EBioMedicine 2, 1500-1506 (2015)
Publ. Version/Full Text DOI
Open Access Gold
Creative Commons Lizenzvertrag
Changes in x-ray attenuating tissue caused by lung disorders like emphysema or fibrosis are subtle and thus only resolved by high-resolution computed tomography (CT). The structural reorganization, however, is of strong influence for lung function. Dark-field CT (DFCT), based on small-angle scattering of x-rays, reveals such structural changes even at resolutions coarser than the pulmonary network and thus provides access to their anatomical distribution. In this proof-of-concept study we present x-ray in vivo DFCTs of lungs of a healthy, an emphysematous and a fibrotic mouse. The tomographies show excellent depiction of the distribution of structural - and thus indirectly functional - changes in lung parenchyma, on single-modality slices in dark field as well as on multimodal fusion images. Therefore, we anticipate numerous applications of DFCT in diagnostic lung imaging. We introduce a scatter-based Hounsfield Unit (sHU) scale to facilitate comparability of scans. In this newly defined sHU scale, the pathophysiological changes by emphysema and fibrosis cause a shift towards lower numbers, compared to healthy lung tissue.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Dark-field Computed Tomography ; Dark-field Imaging ; Pulmonary Emphysema ; Pulmonary Fibrosis ; X-ray Phase-contrast Imaging
ISSN (print) / ISBN 2352-3964
e-ISSN 2352-3964
Journal EBioMedicine
Quellenangaben Volume: 2, Issue: 10, Pages: 1500-1506 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place Amsterdam [u.a.]
Reviewing status Peer reviewed