Open Access Gold as soon as Publ. Version/Full Text is submitted to ZB.
Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation.
Nat. Commun. 6:8658 (2015)
Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P<5 × 10(-8)) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1 and AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered.
Edit extra informations Login
Publication type Article: Journal article
Document type Scientific Article
ISSN (print) / ISBN 2041-1723
Journal Nature Communications
Quellenangaben Volume: 6, Article Number: 8658
Publisher Nature Publishing Group
Publishing Place London
Reviewing status Peer reviewed