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Papandonatos, G.D.* ; Pan, Q.* ; Pajewski, N.M.* ; Delahanty, L.M.* ; Peter, I.* ; Erar, B.* ; Ahmad, S.* ; Harden, M.* ; Chen, L.* ; Fontanillas, P.* ; GIANT Consortium (Albrecht, E. ; Gieger, C. ; Grallert, H. ; Heid, I.M. ; Illig, T. ; Müller-Nurasyid, M. ; Peters, A. ; Thorand, B. ; Wichmann, H.-E.) ; Wagenknecht, L.E.* ; Kahn, S.E.* ; Wing, R.R.* ; Jablonski, K.A.* ; Huggins, G.S.* ; Knowler, W.C.* ; Florez, J.C* ; McCaffery, J.M.* ; Franks, P.W.* ; Diabetes Prevention Program (*) ; Look AHEAD Research Group (*)

Genetic predisposition to weight loss and regain with lifestyle intervention: Analyses from the Diabetes Prevention Program and the Look AHEAD randomized controlled trials.

Diabetes 64, 4312-4321 (2015)
Verlagsversion Forschungsdaten DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
We investigated the genetic overlap between Alzheimer’s disease (AD) and Parkinson’s disease (PD). Using summary statistics (P-values) from large recent genome-wide association studies (GWAS) (total n=89 904 individuals), we sought to identify single nucleotide polymorphisms (SNPs) associating with both AD and PD. We found and replicated association of both AD and PD with the A allele of rs393152 within the extended MAPT region on chromosome 17 (meta analysis P-value across five independent AD cohorts=1.65 × 10−7). In independent datasets, we found a dose-dependent effect of the A allele of rs393152 on intra-cerebral MAPT transcript levels and volume loss within the entorhinal cortex and hippocampus. Our findings identify the tau-associated MAPT locus as a site of genetic overlap between AD and PD, and extending prior work, we show that the MAPT region increases risk of Alzheimer’s neurodegeneration.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
ISSN (print) / ISBN 0012-1797
e-ISSN 1939-327X
Zeitschrift Diabetes
Quellenangaben Band: 64, Heft: 12, Seiten: 4312-4321 Artikelnummer: , Supplement: ,
Verlag American Diabetes Association
Verlagsort Alexandria, VA.
Begutachtungsstatus Peer reviewed