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Huang, R.J.* ; Wei, Y.* ; Hung, R.J.* ; Liu, G.* ; Su, L.* ; Zhang, R.* ; Zong, X.* ; Zhang, Z.F.* ; Morgenstern, H.* ; Brüske, I. ; Heinrich, J. ; Hong, Y.C.* ; Kim, J.H.* ; Cote, M.L.* ; Wenzlaff, A.* ; Schwartz, A.G.* ; Stücker, I.* ; McLaughlin, J.* ; Marcus, M.W.* ; Davies, M.P.A.* ; Liloglou, T.* ; Field, J.K.* ; Matsuo, K.* ; Barnett, M.* ; Thornquist, M.* ; Goodman, G.* ; Wang, Y.* ; Chen, S.* ; Yang, P.* ; Duell, E.J.* ; Andrew, A.S.* ; Lazarus, P.* ; Muscat, J.* ; Woll, P.J.* ; Horsman, J.* ; Teare, M.D.* ; Flugelman, A.* ; Rennert, G.* ; Zhang, Y.* ; Brenner, H.* ; Stegmaier, C.* ; van der Heijden, E.H.F.M.* ; Aben, K.K.* ; Kiemeney, L.* ; Barros-Dios, J.M.* ; Pérez-Ríos, M.* ; Ruano-Ravina, A.* ; Caporaso, N.E.* ; Bertazzi, P.A.* ; Landi, M.T.* ; Dai, J.C.* ; Shen, H.* ; Fernandez-Tardon, G.* ; Rodriguez-Suarez, M.* ; Tardón, A.* ; Christiani, D.C.*

Associated links among smoking, chronic obstructive pulmonary disease, and small cell lung cancer: A pooled analysis in the International Lung Cancer Consortium.

EBioMedicine 2, 1677-1685 (2015)
Publ. Version/Full Text DOI
Open Access Gold
Creative Commons Lizenzvertrag
Background: The high relapse and mortality rate of small-cell lung cancer (SCLC) fuels the need for epidemiologic study to aid in its prevention. Methods: We included 24 studies from the ILCCO collaboration. Random-effects panel logistic regression and cubic spline regression were used to estimate the effects of smoking behaviors on SCLC risk and explore their non-linearity. Further, we explored whether the risk of smoking on SCLC was mediated through COPD. Findings: Significant dose-response relationships of SCLC risk were observed for all quantitative smoking variables. Smoking pack-years were associated with a sharper increase of SCLC risk for pack-years ranged 0 to approximately 50. The former smokers with longer cessation showed a 43%quit_for_5-9years to 89%quit_for_≥20years declined SCLC risk vs. subjects who had quit smoking <5years. Compared with non-COPD subjects, smoking behaviors showed a significantly higher effect on SCLC risk among COPD subjects, and further, COPD patients showed a 1.86-fold higher risk of SCLC. Furthermore, smoking behaviors on SCLC risk were significantly mediated through COPD which accounted for 0.70% to 7.55% of total effects. Interpretation: This is the largest pooling study that provides improved understanding of smoking on SCLC, and further demonstrates a causal pathway through COPD that warrants further experimental study.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Causal Mediation Analysis ; Chronic Obstructive Pulmonary Disease ; Multicenter Pooling ; Small Cell Lung Cancer Risk ; Smoking Behaviors
ISSN (print) / ISBN 2352-3964
e-ISSN 2352-3964
Journal EBioMedicine
Quellenangaben Volume: 2, Issue: 11, Pages: 1677-1685 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place Amsterdam [u.a.]
Reviewing status Peer reviewed