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Conrad, M. ; Friedmann Angeli, J.P.F. ; Vandenabeele, P.* ; Stockwell, B.R.*

Regulated necrosis: Disease relevance and therapeutic opportunities.

Nat. Rev. Drug Discov. 15, 348-366 (2016)
Verlagsversion DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The discovery of regulated cell death presents tantalizing possibilities for gaining control over the life-death decisions made by cells in disease. Although apoptosis has been the focus of drug discovery for many years, recent research has identified regulatory mechanisms and signalling pathways for previously unrecognized, regulated necrotic cell death routines. Distinct critical nodes have been characterized for some of these alternative cell death routines, whereas other cell death routines are just beginning to be unravelled. In this Review, we describe forms of regulated necrotic cell death, including necroptosis, the emerging cell death modality of ferroptosis (and the related oxytosis) and the less well comprehended parthanatos and cyclophilin D-mediated necrosis. We focus on small molecules, proteins and pathways that can induce and inhibit these non-apoptotic forms of cell death, and discuss strategies for translating this understanding into new therapeutics for certain disease contexts.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Mitochondrial Permeability Transition; Glutathione-peroxidase 4; Nonapoptotic Cell-death; Mixed Lineage Kinase; Small-molecule Inhibitor; Domain-like Protein; Nlrp3 Inflammasome Activation; Alpha-dependent Apoptosis; Transient Focal Ischemia; Kappa-b Activation
ISSN (print) / ISBN 1474-1776
Quellenangaben Band: 15, Heft: 5, Seiten: 348-366 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Begutachtungsstatus Peer reviewed