PuSH - Publikationsserver des Helmholtz Zentrums München

Ma, X. ; Prakash, J. ; Ruscitti, F.* ; Glasl, S. ; Stellari, F.F.* ; Villetti, G.* ; Ntziachristos, V.

Assessment of asthmatic inflammation using hybrid fluorescence molecular tomography-X-ray computed tomography.

J. Biomed. Opt. 21:15009 (2016)
DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Nuclear imaging plays a critical role in asthma research but is limited in its readings of biology due to the short-lived signals of radio-isotopes. We employed hybrid fluorescence molecular tomography (FMT) and x-ray computed tomography (XCT) for the assessment of asthmatic inflammation based on resolving cathepsin activity and matrix metalloproteinase activity in dust mite, ragweed, and Aspergillus species-challenged mice. The reconstructed multimodal fluorescence distribution showed good correspondence with ex vivo cryosection images and histological images, confirming FMT-XCT as an interesting alternative for asthma research.
Altmetric
Weitere Metriken?
Zusatzinfos bearbeiten [➜Einloggen]
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Asthmatic Inflammation ; Dust Mite, Ragweed, And Aspergillus Species-challenged Mouse Model ; Fluorescence Molecular Tomography ; Multimodality Imaging ; X-ray Computed Tomography; Airway Inflammation; Mouse Models; Immunology; Contrast; Mice; Ct
ISSN (print) / ISBN 1083-3668
e-ISSN 1560-2281
Quellenangaben Band: 21, Heft: 1, Seiten: , Artikelnummer: 15009 Supplement: ,
Verlag SPIE
Verlagsort Bellingham
Begutachtungsstatus Peer reviewed