New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.
Nat. Commun. 7:10495 (2016)
To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Genome-wide Association; Mass Index; Insulin-resistance; Common Variants; Genetic Architecture; Susceptibility Loci; Identifies Common; Provides Insights; Energy-balance; Cutaneous Nevi
ISSN (print) / ISBN 2041-1723
Zeitschrift Nature Communications
Quellenangaben Band: 7, Artikelnummer: 10495
Verlag Nature Publishing Group