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The tumor suppressor p53 connects ribosome biogenesis to cell cycle control: A double-edged sword.

Oncotarget 1, 43-47 (2010)
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Since its first description more than 30 years ago p53 has become a paradigm for a protein with versatile functions. P53 sensitizes a large variety of genetic alterations and has been entitled the guardian of the genome. Stabilization of p53 upon DNA damage is accompanied by a complex pattern of modifications, which ascertain the cellular response either in the direction of a reversible or irreversible cell cycle arrest or programmed cell death. More recently it became evident that p53 also responds to non-genotoxic cell stress, in particular if ribosome biogenesis is affected.
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Publication type Article: Journal article
Document type Scientific Article
Keywords PEBOW-COMPLEX; DNA-DAMAGE; PROTEIN; MUTATIONS; DISRUPTION; RPS14; BOP1; PES1; PROLIFERATION; STABILIZATION
ISSN (print) / ISBN 1949-2553
e-ISSN 1949-2553
Journal OncoTarget
Quellenangaben Volume: 1, Issue: 1, Pages: 43-47 Article Number: , Supplement: ,
Publisher Impact Journals LLC
Reviewing status Peer reviewed