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Gamboa-Dominguez, A.* ; Seidl, S.* ; Reyes-Gutierrez, E.* ; Hermannstädter, C.* ; Quintanilla-Martinez, L. ; Busch, R.* ; Höfler, H. ; Fend, F.* ; Luber, B.*

Prognostic significance of p21WAF1/CIP1, p27Kip1, p53 and E-cadherin expression in gastric cancer.

J. Clin. Pathol. 60, 756-761 (2007)
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
astric carcinoma is characterised by numerous genetic and epigenetic alterations that influence cell cycle progression, apoptosis and DNA repair. These alterations include down-regulation of the cyclin-dependent kinase (CDK) inhibitors p21(WAF1/CIP1) and p27(Kip1), and mutations of the tumour suppressor protein p53 and the cell adhesion molecule E-cadherin. Combined evaluation of the prognostic significance of these alterations has not been reported in Mexican Mestizo patients. AIMS: To evaluate p21(WAF1/CIP1), p27(Kip1), p53 and E-cadherin protein expression, including mutant E-cadherin variants with deletion of exon 8 (del 8) or 9 (del 9), in gastric cancer from Mexican patients. METHODS: Immunohistochemistry for the above-mentioned markers, including mutation-specific E-cadherin antibodies, was carried out in 69 gastric carcinomas; expression levels were correlated with histotype, tumour stage and prognosis. RESULTS: Expression of p21(WAF1/CIP1) alone or in combination with p27(Kip1) or in the absence of p53 was associated with favourable prognosis. Staining of del 8 and del 9 E-cadherin was found exclusively in patients negative for p53 and positive for p21(WAF1/CIP1), suggesting that the p21(WAF1/CIP1) regulatory function of p53 was intact. CONCLUSION: Combined evaluation of the prognostic significance of cell cycle regulators and E-cadherin should be performed. Even though patients negative for p53 and positive for p21(WAF1/CIP1) have a favourable prognosis, it may have a negative influence on prognosis if they acquire in addition E-cadherin mutations which have been shown previously to be associated with poor survival.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter p21WAF1/CIP1; p27Kip1; p53; E-cadherin; gastric cancer
ISSN (print) / ISBN 0021-9746
e-ISSN 1472-4146
Quellenangaben Band: 60, Heft: 7, Seiten: 756-761 Artikelnummer: , Supplement: ,
Verlag BMJ Publishing Group
Begutachtungsstatus Peer reviewed