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Epigenetic germline inheritance of diet-induced obesity and insulin resistance.
Nat. Genet. 48, 497-499 (2016)
DOI
There is considerable controversy regarding epigenetic inheritance in mammalian gametes. Using in vitro fertilization to ensure exclusive inheritance via the gametes, we show that a parental high-fat diet renders offspring more susceptible to developing obesity and diabetes in a sex- and parent of origin-specific mode. The epigenetic inheritance of acquired metabolic disorders may contribute to the current obesity and diabetes pandemic.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Body-mass Index; High-fat Diet; Maternal Obesity; Programs; Contribute; Mammals; Alters; Mice
ISSN (print) / ISBN 1061-4036
e-ISSN 1546-1718
Zeitschrift Nature Genetics
Quellenangaben Band: 48, Heft: 5, Seiten: 497-499 Artikelnummer: , Supplement: ,
Verlag Nature America
Verlagsort New York, NY
Begutachtungsstatus peer-reviewed