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Epigenetic germline inheritance of diet-induced obesity and insulin resistance.

Nat. Genet. 48, 497-499 (2016)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
There is considerable controversy regarding epigenetic inheritance in mammalian gametes. Using in vitro fertilization to ensure exclusive inheritance via the gametes, we show that a parental high-fat diet renders offspring more susceptible to developing obesity and diabetes in a sex- and parent of origin-specific mode. The epigenetic inheritance of acquired metabolic disorders may contribute to the current obesity and diabetes pandemic.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Body-mass Index; High-fat Diet; Maternal Obesity; Programs; Contribute; Mammals; Alters; Mice
Reviewing status