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Epigenetic germline inheritance of diet-induced obesity and insulin resistance.
Nat. Genet. 48, 497-499 (2016)
There is considerable controversy regarding epigenetic inheritance in mammalian gametes. Using in vitro fertilization to ensure exclusive inheritance via the gametes, we show that a parental high-fat diet renders offspring more susceptible to developing obesity and diabetes in a sex- and parent of origin-specific mode. The epigenetic inheritance of acquired metabolic disorders may contribute to the current obesity and diabetes pandemic.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Body-mass Index; High-fat Diet; Maternal Obesity; Programs; Contribute; Mammals; Alters; Mice