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Horowitz, J.C.* ; Osterholzer, J.J.* ; Marazioti, A.* ; Stathopoulos, G.T.

"Scar-cinoma": Viewing the fibrotic lung mesenchymal cell in the context of cancer biology.

Eur. Respir. J. 47, 1842-1854 (2016)
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Lung cancer and pulmonary fibrosis are common, yet distinct, pathological processes that represent urgent unmet medical needs. Striking clinical and mechanistic parallels exist between these distinct disease entities. The goal of this article is to examine lung fibrosis from the perspective of cancer-associated phenotypic hallmarks, to discuss areas of mechanistic overlap and distinction, and to highlight profibrotic mechanisms that contribute to carcinogenesis. Ultimately, we speculate that such comparisons might identify opportunities to leverage our current understanding of the pathobiology of each disease process in order to advance novel therapeutic approaches for both. We anticipate that such "outside the box" concepts could be translated to a more precise and individualised approach to fibrotic diseases of the lung.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Idiopathic-pulmonary-fibrosis; Fas-induced Apoptosis; Extracellular-matrix; Tumor Stroma; In-vitro; Proliferative Characteristics; Fibroblast Accumulation; Macrophage Plasticity; Exudate Macrophages; Precision Medicine
ISSN (print) / ISBN 0903-1936
e-ISSN 1399-3003
Quellenangaben Band: 47, Heft: 6, Seiten: 1842-1854 Artikelnummer: , Supplement: ,
Verlag European Respiratory Society
Verlagsort Sheffield
Begutachtungsstatus Peer reviewed