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Hergeth, S.P.* ; Schneider, R.*

The H1 linker histones: Multifunctional proteins beyond the nucleosomal core particle.

EMBO Rep. 16, 1439-1453 (2015)
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The linker histone H1 family members are a key component of chromatin and bind to the nucleosomal core particle around the DNA entry and exit sites. H1 can stabilize both nucleosome structure and higher-order chromatin architecture. In general, H1 molecules consist of a central globular domain with more flexible tail regions at both their N- and C-terminal ends. The existence of multiple H1 subtypes and a large variety of posttranslational modifications brings about a considerable degree of complexity and makes studying this protein family challenging. Here, we review recent progress in understanding the function of linker histones and their subtypes beyond their role as merely structural chromatin components. We summarize current findings on the role of H1 in heterochromatin formation, transcriptional regulation and embryogenesis with a focus on H1 subtypes and their specific modifications.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Chromatin ; Epigenetics ; Linker Histone ; Modifications ; Subtypes
ISSN (print) / ISBN 1469-221X
e-ISSN 1469-3178
Zeitschrift EMBO Reports
Quellenangaben Band: 16, Heft: 11, Seiten: 1439-1453 Artikelnummer: , Supplement: ,
Verlag EMBO Press
Begutachtungsstatus Peer reviewed