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Bheda, P.* ; Schneider, R.*

Epigenetics reloaded: The single-cell revolution.

Trends Cell Biol. 24, 712-723 (2014)
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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Mechanistically, how epigenetic states are inherited through cellular divisions remains an important open question in the chromatin field and beyond. Defining the heritability of epigenetic states and the underlying chromatin-based mechanisms within a population of cells is complicated due to cell heterogeneity combined with varying levels of stability of these states; thus, efforts must be focused toward single-cell analyses. The approaches presented here constitute the forefront of epigenetics research at the single-cell level using classic and innovative methods to dissect epigenetics mechanisms from the limited material available in a single cell. This review further outlines exciting future avenues of research to address the significance of epigenetic heterogeneity and the contributions of microfluidics technologies to single-cell isolation and analysis.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Epigenetics ; Epigenomics ; Live Cell ; Microfluidics ; Single Cell
ISSN (print) / ISBN 0962-8924
e-ISSN 1879-3088
Quellenangaben Band: 24, Heft: 11, Seiten: 712-723 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Cambridge
Begutachtungsstatus Peer reviewed