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Reappraisal of GIP pharmacology for metabolic diseases.

Trends Mol. Med. 22, 359-376 (2016)
Open Access Green as soon as Postprint is submitted to ZB.
Glucagon-like peptide-1 (GLP-1) analogs are considered the best current medicines for type 2 diabetes (T2D) and obesity due to their actions in lowering blood glucose and body weight. Despite similarities to GLP-1, glucose-dependent insulinotropic polypeptide (GIP) has not been extensively pursued as a medical treatment for T2D. This is largely based on observations of diminished responses of GIP to lower blood glucose in select patients, as well as evidence from rodent knockout models implying that GIP promotes obesity. These findings have prompted the belief in some, that inhibiting GIP action might be beneficial for metabolic diseases. However, a growing body of new evidence - including data based on refined genetically modified models and improved pharmacological agents - suggests a paradigm shift on how the GIP system should be manipulated for metabolic benefits.
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Publication type Article: Journal article
Document type Review
Keywords Dependent Insulinotropic Polypeptide; Gastric-inhibitory Polypeptide; Glucagon-like Peptide-1; High-fat Diet; Pancreatic Beta-cells; Improves Glucose-tolerance; Type-2 Diabetes-mellitus; Receptor Knockout Mice; Rat Adipose-tissue; Blood-glucose
Reviewing status