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Della Torre, S.* ; Mitro, N.* ; Fontana, R.* ; Gomaraschi, M.* ; Favari, E.* ; Recordati, C.* ; Lolli, F.* ; Quagliarini, F. ; Meda, C.* ; Ohlsson, C.* ; Crestani, M.* ; Uhlenhaut, N.H. ; Calabresi, L.* ; Maggi, A.*

An essential role for liver ERα in coupling hepatic metabolism to the reproductive cycle.

Cell Rep. 15, 360-371 (2016)
Verlagsversion Anhang DOI
Open Access Gold
Creative Commons Lizenzvertrag
Lipoprotein synthesis is controlled by estrogens, but the exact mechanisms underpinning this regulation and the role of the hepatic estrogen receptor α (ERα) in cholesterol physiology are unclear. Utilizing a mouse model involving selective ablation of ERα in the liver, we demonstrate that hepatic ERα couples lipid metabolism to the reproductive cycle. We show that this receptor regulates the synthesis of cholesterol transport proteins, enzymes for lipoprotein remodeling, and receptors for cholesterol uptake. Additionally, ERα is indispensable during proestrus for the generation of high-density lipoproteins efficient in eliciting cholesterol efflux from macrophages. We propose that a specific interaction with liver X receptor α (LXRα) mediates the broad effects of ERα on the hepatic lipid metabolism.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Cholesterol Efflux Capacity; Estrogen-receptor; Fatty Liver; Gene-expression; Lipoprotein Metabolism; Postmenopausal Women; Binding-sites; Mouse-liver; X-receptor; A-i
ISSN (print) / ISBN 2211-1247
e-ISSN 2211-1247
Zeitschrift Cell Reports
Quellenangaben Band: 15, Heft: 2, Seiten: 360-371 Artikelnummer: , Supplement: ,
Verlag Cell Press
Verlagsort Cambridge
Begutachtungsstatus Peer reviewed