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Kamieniarz, K.* ; Izzo, A.* ; Dundr, M.* ; Tropberger, P.* ; Ozretic, L.* ; Kirfel, J.* ; Scheer, E.* ; Tropel, P.* ; Wisniewski, J.R.* ; Tora, L.* ; Viville, S.* ; Buettner, R.* ; Schneider, R.*

A dual role of linker histone H1.4 Lys 34 acetylation in transcriptional activation.

Genes Dev. 26, 797-802 (2012)
DOI Verlagsversion bestellen
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The linker histone H1 is a key player in chromatin organization, yet our understanding of the regulation of H1 functions by post-translational modifications is very limited. We provide here the first functional characterization of H1 acetylation. We show that H1.4K34 acetylation (H1.4K34ac) is mediated by GCN5 and is preferentially enriched at promoters of active genes, where it stimulates transcription by increasing H1 mobility and recruiting a general transcription factor. H1.4K34ac is dynamic during spermatogenesis and marks undifferentiated cells such as induced pluripotent stem (iPS) cells and testicular germ cell tumors. We propose a model for H1.4K34ac as a novel regulator of chromatin function with a dual role in transcriptional activation.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
ISSN (print) / ISBN 0890-9369
e-ISSN 1549-5477
Zeitschrift Genes and Development
Quellenangaben Band: 26, Heft: 8, Seiten: 797-802 Artikelnummer: , Supplement: ,
Verlag Cold Spring Harbor Laboratory Press
Begutachtungsstatus Peer reviewed