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Cohen, I.R.* ; Poreba, E.* ; Kamieniarz, K.* ; Schneider, R.*

Histone modifiers in cancer: Friends or foes?

Genes Cancer 2, 631-647 (2011)
DOI Verlagsversion bestellen
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Covalent modifications of histones can regulate all DNA-dependent processes. In the last few years, it has become more and more evident that histone modifications are key players in the regulation of chromatin states and dynamics as well as in gene expression. Therefore, histone modifications and the enzymatic machineries that set them are crucial regulators that can control cellular proliferation, differentiation, plasticity, and malignancy processes. This review discusses the biology and biochemistry of covalent histone posttranslational modifications (PTMs) and evaluates the dual role of their modifiers in cancer: as oncogenes that can initiate and amplify tumorigenesis or as tumor suppressors.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Acetylation ; Cancer ; Chromatin ; Histone Modifications ; Methylation ; Phosphorylation
ISSN (print) / ISBN 1947-6019
e-ISSN 1947-6027
Zeitschrift Genes and Cancer
Quellenangaben Band: 2, Heft: 6, Seiten: 631-647 Artikelnummer: , Supplement: ,
Verlag Sage
Verlagsort Thousand Oaks, Calif.
Begutachtungsstatus Peer reviewed