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Infantino, S.* ; Benz, B.* ; Waldmann, T.* ; Jung, M.* ; Schneider, R.* ; Reth, M.*

Arginine methylation of the B cell antigen receptor promotes differentiation.

J. Exp. Med. 207, 711-719 (2010)
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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Signals processed through the B cell antigen receptor (BCR) control both the proliferation and differentiation of B lymphocytes. How these different signaling modes are established at the BCR is poorly understood. We show that a conserved arginine in the tail sequence of the Igalpha subunit of the BCR is methylated by the protein arginine methyltransferase 1. This modification negatively regulates the calcium and PI-3 kinase pathways of the BCR while promoting signals leading to B cell differentiation. Thus, Igalpha arginine methylation can play an important role in specifying the outcome of BCR signaling.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
ISSN (print) / ISBN 0022-1007
e-ISSN 1540-9538
Quellenangaben Band: 207, Heft: 4, Seiten: 711-719 Artikelnummer: , Supplement: ,
Verlag Rockefeller University Press
Begutachtungsstatus Peer reviewed