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Dynamics and interplay of nuclear architecture, genome organization, and gene expression.
Genes Dev. 21, 3027-3043 (2007)
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The organization of the genome in the nucleus of a eukaryotic cell is fairly complex and dynamic. Various features of the nuclear architecture, including compartmentalization of molecular machines and the spatial arrangement of genomic sequences, help to carry out and regulate nuclear processes, such as DNA replication, DNA repair, gene transcription, RNA processing, and mRNA transport. Compartmentalized multiprotein complexes undergo extensive modifications or exchange of protein subunits, allowing for an exquisite dynamics of structural components and functional processes of the nucleus. The architecture of the interphase nucleus is linked to the spatial arrangement of genes and gene clusters, the structure of chromatin, and the accessibility of regulatory DNA elements. In this review, we discuss recent studies that have provided exciting insight into the interplay between nuclear architecture, genome organization, and gene expression.
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Publikationstyp Artikel: Journalartikel
ISSN (print) / ISBN 0890-9369
Zeitschrift Genes and Development
Quellenangaben Band: 21, Heft: 23, Seiten: 3027-3043
Verlag Cold Spring Harbor Laboratory Press
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Functional Epigenetics (IFE)