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Schneider, R.* ; Bannister, A.J.* ; Kouzarides, T.*

Unsafe SETs: Histone lysine methyltransferases and cancer.

Trends Biochem. Sci. 27, 396-402 (2002)
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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Enzymes that covalently modify histones control many cellular processes by affecting gene expression. A new class of these enzymes is the histone lysine methyltransferase family, whose catalytic activity lies within a conserved domain, the SET domain. This article surveys the evidence for a connection between SET-domain-containing proteins and cancer. It proposes that deregulation of SET-domain function has an important role in carcinogenesis.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
ISSN (print) / ISBN 0376-5067
e-ISSN 0968-0004
Quellenangaben Band: 27, Heft: 8, Seiten: 396-402 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Cambridge
Begutachtungsstatus Peer reviewed