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Gut immunity and type 1 diabetes: A mélange of microbes, diet, and host interactions?

Curr. Diab. Rep. 16:60 (2016)
Postprint DOI Order publishers version
Open Access Green
Type 1 diabetes (T1D) is a complex autoimmune disease, and first stages of the disease typically develop early in life. Genetic as well as environmental factors are thought to contribute to the risk of developing autoimmunity against pancreatic beta cells. Several environmental factors, such as breastfeeding or early introduction of solid food, have been associated with increased risk for developing T1D. During the first years of life, the gut microbial community is shaped by the environment, in particular by dietary factors. Moreover, the gut microbiome has been described for its role in shaping the immune system early in life and early data suggest associations between T1D risk and alterations in gut microbial communities. In this article, we discuss environmental factors influencing the colonization process of the gut microbial community. Furthermore, we review possible interactions between the microbiome and the host that might contribute to the risk of developing T1D.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Autoimmunity ; Diet ; Environmental Factors ; Gut Microbiome ; Type 1 Diabetes; Human-milk Oligosaccharides; T-cell Responses; Increased Intestinal Permeability; Butyrate-producing Bacteria; Sulfate-reducing Bacteria; Lactic-acid Bacteria; Chain Fatty-acids; Infant Gut; Commensal Bacteria; Islet Autoimmunity
ISSN (print) / ISBN 1534-4827
e-ISSN 1539-0829
Quellenangaben Volume: 16, Issue: 7, Pages: , Article Number: 60 Supplement: ,
Publisher Springer
Publishing Place Heidelberg [u.a.]
Reviewing status Peer reviewed