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Lederbogen, F.* ; Hummel, J.* ; Fademrecht, C.* ; Krumm, B.* ; Kühner, C.* ; Deuschle, M.* ; Ladwig, K.-H. ; Meisinger, C. ; Wichmann, H.-E. ; Lutz, H.* ; Breivogel, B.*

Flattened circadian cortisol rhythm in type 2 diabetes.

Exp. Clin. Endocrinol. Diabet. 119, 573-575 (2011)
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While altered cortisol concentrations have been observed in subjects with type 2 diabetes their circadian cortisol profile is unknown. Using a cross-sectional design, we studied 63 ambulatory individuals with type 2 diabetes and 916 non-diabetic control subjects of the Cooperative Research in the Region of Augsburg (KORA)-F3 study. Circadian cortisol profiles were derived from saliva cortisol concentrations, determined on a regular weekday upon wake-up (F0), as well as ½ h (F½), 8 (F8) and 14 h (F14) after wake-up. Diabetic subjects exhibited a flattened circadian cortisol profile (rm-ANOVA: F[3,654]=3.41, p=0.02), with lower morning and higher afternoon and evening cortisol concentrations. observed a flattened circadian cortisol rhythm in subjects with type 2 diabetes, providing evidence for a specific HPA system dysfunction.
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Publication type Article: Journal article
Document type Scientific Article
Keywords glucocorticoids; hypothalamic-pituitary-adrenal system; circadian rhythm
ISSN (print) / ISBN 0947-7349
e-ISSN 1439-3646
Quellenangaben Volume: 119, Issue: 9, Pages: 573-575 Article Number: , Supplement: ,
Publisher Thieme
Publishing Place Stuttgart
Reviewing status Peer reviewed