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S-nitrosylation of nuclear proteins: New pathways in regulation of gene expression.

Adv. Bot. Res. 77, 15-39 (2016)
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Nitric oxide (NO) is a reactive free radical with pleiotropic function that is not only involved in regulation of plant growth and development, but also in the response to biotic and abiotic stressors. It mainly acts by posttranslationally modifying proteins. The most important mode of action of NO is protein S-nitrosylation, the covalent attachment of an NO group to the thiol side of protein cysteine residues. Other major types of NO-dependent modifications are metal nitrosylation and tyrosine nitration. NO can regulate gene expression at different levels. On one side, it can initiate signalling cascades or modify proteins involved in signal transduction pathways. On the other side, redox-sensitive transcription factors can be also target for S-nitrosylation, and NO can also affect redox-dependent nuclear transport of some proteins. This suggests that NO plays a pivotal role in regulating transcription and/or general nuclear metabolism in plants.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Gene Expression ; Nuclear Proteins ; Posttranslational Modification ; Protein S-nitrosylation ; Transcriptional Regulation; Adenosyl-l-homocysteine; Cytosolic Glyceraldehyde-3-phosphate Dehydrogenase; Systemic Acquired-resistance; Plant-disease Resistance; Transcription Factor Fit; Oxide-responsive Genes; Dna-binding Activity; Induced Cell-death; Nitric-oxide; Arabidopsis-thaliana
ISSN (print) / ISBN 0065-2296
Quellenangaben Volume: 77, Issue: , Pages: 15-39 Article Number: , Supplement: ,
Publisher Academic Press
Publishing Place San Diego, Calif. [u.a.]
Reviewing status Peer reviewed