Cross-cancer genome-wide analysis of lung, ovary, breast, prostate and colorectal cancer reveals novel pleiotropic associations.
Cancer Res. 76, 5103-5114 (2016)
Identifying genetic variants with pleiotropic associations can uncover common pathways influencing multiple cancers. We took a two-staged approach to conduct genome-wide association studies for lung, ovary, breast, prostate and colorectal cancer from the GAME-ON/GECCO Network (61,851 cases, 61,820 controls) to identify pleiotropic loci. Findings were replicated in independent association studies (55,789 cases, 330,490 controls). We identified a novel pleiotropic association at 1q22 involving breast and lung squamous cell carcinoma, with eQTL analysis showing an association with ADAM15/THBS3 gene expression in lung. We also identified a known breast cancer locus CASP8/ALS2CR12 associated with prostate cancer, a known cancer locus at CDKN2B-AS1 with different variants associated with lung adenocarcinoma and prostate cancer and confirmed the associations of a breast BRCA2 locus with lung and serous ovarian cancer. This is the largest study to date examining pleiotropy across multiple cancer-associated loci, identifying common mechanisms of cancer development and progression.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Susceptibility Loci; Identifies 2; Genetic Polymorphisms; Aggressive Prostate; African Ancestry; Common Variants; Gastric-cancer; Cell Carcinoma; Risk Loci; Metaanalysis
ISSN (print) / ISBN 0008-5472
Zeitschrift Cancer Research
Quellenangaben Band: 76, Heft: 17, Seiten: 5103-5114
Verlag American Association for Cancer Research (AACR), HighWire Press
Verlagsort Philadelphia, Pa.