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Fehringer, G.* ; Kraft, P.* ; Pharoah, P.D.* ; Eeles, R.A.* ; Chatterjee, N.* ; Schumacher, F.R.* ; Schildkraut, J.M.* ; Lindström, S.* ; Brennan, P.* ; Bickeböller, H.* ; Houlston, R.S.* ; Landi, M.T.* ; Caporaso, N.E.* ; Risch, A.* ; Amin Al Olama, A.* ; Berndt, S.I.* ; Giovannucci, E.* ; Grönberg, H.* ; Kote-Jarai, Z.* ; Ma, J.* ; Muir, K.* ; Stampfer, M.J.* ; Stevens, V.L.* ; Wiklund, F.* ; Willett, W.C.* ; Goode, E.L.* ; Permuth, J.B.* ; Risch, H.A.* ; Reid, B.M.* ; Bézieau, S.* ; Brenner, H.* ; Chan, A.T.* ; Chang-Claude, J.* ; Hudson, T.J.* ; Kocarnik, J.M.* ; Newcomb, P.A.* ; Schoen, R.E.* ; Slattery, M.L.* ; White, E.S.* ; Adank, M.A.* ; Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON) ; Ahsan, H.* ; Aittomäki, K.* ; Baglietto, L.* ; Blomquist, C.H.* ; Canzian, F.* ; Czene, K.* ; Dos Santos Silva, I.* ; Eliassen, A.H.* ; Figueroa, J.D.* ; Flesch-Janys, D.* ; Fletcher, O.* ; Garcia-Closas, M.* ; Gaudet, M.M.* ; Johnson, N.* ; Hall, P.* ; Hazra, A.* ; Hein, R.* ; Hofman, A.* ; Hopper, J.L.* ; Irwanto, A.* ; Johansson, M.* ; Kaaks, R.* ; Kibriya, M.G.* ; Lichtner, P. ; Liu, J.J.* ; Lund, E.* ; Makalic, E.* ; Meindl, A.* ; Müller-Myhsok, B.* ; Muranen, T.A.* ; Nevanlinna, H.* ; Peeters, P.H.* ; Peto, J.* ; Prentice, R.L.* ; Rahman, N.* ; Sánchez, M.J.* ; Schmidt, D.F.* ; Schmutzler, R.K.* ; Southey, M.C.* ; Tamimi, R.M.* ; Travis, R.C.* ; Turnbull, C.* ; Uitterlinden, A.G.* ; Wang, Z.* ; Whittemore, A.S.* ; Yang, X.R.* ; Zheng, W.* ; Rafnar, T.* ; Gudmundsson, J.* ; Stacey, S.N.* ; Stefansson, K.* ; Sulem, P.* ; Chen, Y.A.* ; Tyrer, J.P.* ; Christiani, D.C.* ; Wei, Y.* ; Shen, H.* ; Hu, Z.* ; Shu, X.O.* ; Shiraishi, K.* ; Takahashi, A.* ; Bossé, Y.* ; Obeidat, M.* ; Nickle, D.C.* ; Timens, W.* ; Freedman, M.L.* ; Li, Q.L.* ; Seminara, D.* ; Chanock, S.J.* ; Gong, J.* ; Peters, U.* ; Gruber, S.B.* ; Colorectal Transdisciplinary Study (CORECT) ; Amos, C.I.* ; Sellers, T.A.* ; Easton, D.F.* ; Hunter, D.J.* ; Haiman, C.A.* ; African American Breast Cancer Consortium (AABC) ; African Ancestry Prostate Cancer Consortium (AAPC) ; Henderson, B.E.* ; Hung, R.J.*

Cross-cancer genome-wide analysis of lung, ovary, breast, prostate and colorectal cancer reveals novel pleiotropic associations.

Cancer Res. 76, 5103-5114 (2016)
Publishers Version Postprint Research data DOI PMC
Open Access Green
as soon as is submitted to ZB.
Identifying genetic variants with pleiotropic associations can uncover common pathways influencing multiple cancers. We took a two-staged approach to conduct genome-wide association studies for lung, ovary, breast, prostate and colorectal cancer from the GAME-ON/GECCO Network (61,851 cases, 61,820 controls) to identify pleiotropic loci. Findings were replicated in independent association studies (55,789 cases, 330,490 controls). We identified a novel pleiotropic association at 1q22 involving breast and lung squamous cell carcinoma, with eQTL analysis showing an association with ADAM15/THBS3 gene expression in lung. We also identified a known breast cancer locus CASP8/ALS2CR12 associated with prostate cancer, a known cancer locus at CDKN2B-AS1 with different variants associated with lung adenocarcinoma and prostate cancer and confirmed the associations of a breast BRCA2 locus with lung and serous ovarian cancer. This is the largest study to date examining pleiotropy across multiple cancer-associated loci, identifying common mechanisms of cancer development and progression.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Susceptibility Loci; Identifies 2; Genetic Polymorphisms; Aggressive Prostate; African Ancestry; Common Variants; Gastric-cancer; Cell Carcinoma; Risk Loci; Metaanalysis
Reviewing status