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Martínez-Martínez, M.Á.* ; Romero, C.* ; Fernandez, V.* ; Cárdenas, A.* ; Götz, M. ; Borrell, V.*

A restricted period for formation of outer subventricular zone defined by Cdh1 and Trnp1 levels.

Nat. Commun. 7:11812 (2016)
Verlagsversion Anhang DOI
Open Access Gold
Creative Commons Lizenzvertrag
The outer subventricular zone (OSVZ) is a germinal layer playing key roles in the development of the neocortex, with particular relevance in gyrencephalic species such as human and ferret, where it contains abundant basal radial glia cells (bRGCs) that promote cortical expansion. Here we identify a brief period in ferret embryonic development when apical RGCs generate a burst of bRGCs that become founders of the OSVZ. After this period, bRGCs in the OSVZ proliferate and self-renew exclusively locally, thereby forming a self-sustained lineage independent from the other germinal layers. The time window for the brief period of OSVZ bRGC production is delineated by the coincident downregulation of Cdh1 and Trnp1, and their upregulation reduces bRGC production and prevents OSVZ seeding. This mechanism in cortical development may have key relevance in brain evolution and disease.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Mammalian Cerebral-cortex; Radial Glia; In-vivo; Human Neocortex; Spindle Orientation; Progenitor Cells; Visual-cortex; Lissencephalic Primate; Cortical Neurogenesis; Embryonic Neocortex
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Zeitschrift Nature Communications
Quellenangaben Band: 7, Heft: , Seiten: , Artikelnummer: 11812 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Begutachtungsstatus Peer reviewed