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Soliman, D. ; Tserevelakis, G.J.* ; Omar, M. ; Ntziachristos, V.

Combined label-free optical and optoacoustic imaging of model organisms at mesoscopy and microscopy resolutions.

Proc. SPIE 9708:97083B (2016)
Verlagsversion DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
We present a multi-scale imaging system that integrates five optoacoustic and multi-photon modalities into the same device. The hybrid microscope offers a unique zoom-in ability by allowing for optoacoustic microscopy and mesoscopy scans of the sample within the same imaging framework. Furthermore, by combining several label-free modalities, we are able to visualize a broad range of anatomical features, taking advantage of their complementary contrast mechanisms. We characterize the spatial resolution and relative orientation of the different sub-modalities and demonstrate the system's performance by the imaging of several model organisms ex vivo. The presented ability to dynamically vary scanning volume and resolution together with its multi-contrast and label-free imaging capabilities make the hybrid microscope a promising tool for comprehensive biological imaging.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Mesoscopy
ISSN (print) / ISBN 0277-786X
e-ISSN 1996-756X
Konferenztitel Photons Plus Ultrasound: Imaging and Sensing 2016
Konferzenzdatum 14-17 February 2017
Konferenzort San Francisco, CA, USA
Zeitschrift Proceedings of SPIE
Quellenangaben Band: 9708, Heft: , Seiten: , Artikelnummer: 97083B Supplement: ,
Verlag SPIE
Begutachtungsstatus Peer reviewed