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Stahl, V.* ; Maier, F.* ; Freitag, M.T.* ; Floca, R.O.* ; Berger, M.C.* ; Umathum, R.* ; Berriel Diaz, M. ; Herzig, S. ; Weber, M.A.* ; Dimitrakopoulou-Strauss, A.* ; Rink, K.* ; Bachert, P.* ; Ladd, M.E.* ; Nagel, A.M.*

In vivo assessment of cold stimulation effects on the fat fraction of brown adipose tissue using DIXON MRI.

J. Magn. Reson. Imaging 45, 369-380 (2017)
Verlagsversion Postprint Forschungsdaten DOI
Open Access Green
PURPOSE: To evaluate the volume and changes of human brown adipose tissue (BAT) in vivo following exposure to cold using magnetic resonance imaging (MRI). MATERIALS AND METHODS: The clavicular region of 10 healthy volunteers was examined with a 3T MRI system. One volunteer participated twice. A cooling vest that was circulated with temperature-controlled water was used to expose each volunteer to a cold environment. Three different water temperature phases were employed: baseline (23°C, 20 min), cooling (12°C, 90 min), and a final warming phase (37°C, 30 min). Temperatures of the water in the circuit, of the body, and at the back skin of the volunteers were monitored with fiberoptic temperature probes. Applying the 2-point DIXON pulse sequence every 5 minutes, fat fraction (FF) maps were determined and evaluated over time to distinguish between brown and white adipose tissue. RESULTS: Temperature measurements showed a decrease of 3.8 ± 1.0°C of the back skin temperature, while the body temperature stayed constant at 37.2 ± 0.9°C. Focusing on the two interscapular BAT depots, a mean FF decrease of -2.9 ± 2.0%/h (P < 0.001) was detected during cold stimulation in a mean absolute volume of 1.31 ± 1.43 ml. Also, a correlation of FF decrease to back skin temperature decrease was observed in all volunteers (correlation coefficients: |r| = [0.51; 0.99]). CONCLUSION: We found that FF decreases in BAT begin immediately with mild cooling of the body and continue during long-time cooling.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Dixon ; Mri ; Brown Adipose Tissue ; Fat Fraction ; Fiberoptic Temperature Measurements; Outdoor Temperature; Adult Humans; Identification; Prevalence; Proton; Water
ISSN (print) / ISBN 1053-1807
e-ISSN 1522-2586
Quellenangaben Band: 45, Heft: 2, Seiten: 369-380 Artikelnummer: , Supplement: ,
Verlag Wiley
Verlagsort Hoboken
Begutachtungsstatus Peer reviewed