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Lymphocyte signaling and activation by the CARMA1-BCL10-MALT1 signalosome.

Biol. Chem. 397, 1315-1333 (2016)
Open Access Green as soon as Postprint is submitted to ZB.
The CARMA1-BCL10-MALT1 (CBM) signalosome triggers canonical NF-κB signaling and lymphocyte activation upon antigen receptor stimulation. Genetic studies in mice and the analysis of human immune pathologies unveiled a critical role of the CBM complex in adaptive immune responses. Great progress has been made in elucidating the fundamental mechanisms that dictate CBM assembly and disassembly. By bridging proximal antigen receptor signaling to downstream signaling pathways, the CBM complex exerts a crucial scaffolding function. Moreover, the MALT1 subunit confers a unique proteolytic activity that is key for lymphocyte activation. Deregulated 'chronic' CBM signaling drives constitutive NF-κB signaling and MALT1 activation, which contribute to the development of autoimmune and inflammatory diseases as well as lymphomagenesis. Thus, the processes that govern CBM activation and function are promising targets for the treatment of immune disorders. Here, we summarize the current knowledge on the functions and mechanisms of CBM signaling in lymphocytes and how CBM deregulations contribute to aberrant signaling in malignant lymphomas.
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Publication type Article: Journal article
Document type Review
Keywords Adaptive Immunity ; Cbm Complex ; Diffuse Large B Cell Lymphomas ; Lymphocyte Signaling; Nf-kappa-b; T-cell-activation; Malt1 Protease Activity; Responsive Inhibitory Domain; Oncogenic Card11 Mutations; Messenger-rna Decay; Kinase-c-theta; Paracaspase Malt1; Antigen-receptor; Immune-responses
ISSN (print) / ISBN 1431-6730
e-ISSN 1437-4315
Quellenangaben Volume: 397, Issue: 12, Pages: 1315-1333 Article Number: , Supplement: ,
Publisher de Gruyter
Publishing Place Berlin
Reviewing status Peer reviewed