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Hybrid multispectral optoacoustic and ultrasound tomography for morphological and physiological brain imaging.

J. Biomed. Opt. 21:86005 (2016)
DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Expanding usage of small animal models in biomedical research necessitates development of technologies for structural, functional, or molecular imaging that can be readily integrated in the biological laboratory. Herein, we consider dual multispectral optoacoustic (OA) and ultrasound tomography based on curved ultrasound detector arrays and describe the performance achieved for hybrid morphological and physiological brain imaging of mice in vivo. We showcase coregistered hemodynamic parameters resolved by OA tomography under baseline conditions and during alterations of blood oxygen saturation. As an internal reference, we provide imaging of abdominal organs. We illustrate the performance advantages of hybrid curved detector ultrasound and OA tomography and discuss immediate and long-term implications of our findings in the context of animal and human studies.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Brain Tomography ; Hybrid Systems ; In Vivo Imaging ; Multispectral Optoacoustic Tomography ; Oxygen Saturation ; Photoacoustic; Ray Computed-tomography; In-vivo; Photoacoustic Tomography; Transducer Array; Contrast Agent; Pet/ct Scanner; Microscopy; Mri; Nanoparticles; Multiphoton
ISSN (print) / ISBN 1083-3668
e-ISSN 1560-2281
Quellenangaben Band: 21, Heft: 8, Seiten: , Artikelnummer: 86005 Supplement: ,
Verlag SPIE
Verlagsort Bellingham
Begutachtungsstatus Peer reviewed