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Trifunovic, D.* ; Arango-González, B.* ; Comitato, A.* ; Barth, M.* ; del Amo, E.M.* ; Kulkarni, M.* ; Sahaboglu, A.* ; Hauck, S.M. ; Urtti, A.* ; Arsenijevic, Y.* ; Ueffing, M.* ; Marigo, V.* ; Paquet-Durand, F.*

HDAC inhibition in the cpfl1 mouse protects degenerating cone photoreceptors in vivo.

Hum. Mol. Genet. 25, 4462-4472 (2016)
Verlagsversion Postprint Anhang DOI
Open Access Green
Cone photoreceptor cell death as it occurs in certain hereditary retinal diseases is devastating, with the affected patients suffering from a loss of accurate and color vision. Regrettably, these hereditary cone diseases are still untreatable to date. Thus, the identification of substances able to block or restrain cone cell death is of primary importance. We studied the neuroprotective effects of a histone deacetylase inhibitor, Trichostatin A (TSA), in a mouse model of inherited, primary cone degeneration (cpfl1). We show that HDAC inhibition protects cpfl1 cones in vitro, in retinal explant cultures. More importantly, in vivo, a single intravitreal TSA injection significantly increased cone survival for up to 16 days post-injection. In addition, the abnormal, incomplete cone migration pattern in the cpfl1 retina was significantly improved by HDAC inhibition. These findings suggest a crucial role for HDAC activity in primary cone degeneration and highlight a new avenue for future therapy developments for cone dystrophies and retinal diseases associated with impaired cone migration.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Vasodilator-stimulated Phosphoprotein; Histone Deacetylase Inhibitors; Retinitis-pigmentosa; Retinal Degeneration; Valproic Acid; Kinase-g; Acetylation; Mice; Phosphorylation; Therapy
ISSN (print) / ISBN 0964-6906
e-ISSN 1460-2083
Quellenangaben Band: 25, Heft: 20, Seiten: 4462-4472 Artikelnummer: , Supplement: ,
Verlag Oxford University Press
Verlagsort Oxford
Begutachtungsstatus Peer reviewed