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High-resolution multispectral optoacoustic tomography of the vascularization and constitutive hypoxemia of cancerous tumors.

Neoplasia 18, 459-467 (2016)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Diversity of the design and alignment of illumination and ultrasonic transducers empower the fine scalability and versatility of optoacoustic imaging. In this study, we implement an innovative high-resolution optoacoustic mesoscopy for imaging the vasculature and tissue oxygenation within subcutaneous and orthotopic cancerous implants of mice in vivo through acquisition of tomographic projections over 180° at a central frequency of 24 MHz. High-resolution volumetric imaging was combined with multispectral functional measurements to resolve the exquisite inner structure and vascularization of the entire tumor mass using endogenous and exogenous optoacoustic contrast. Evidence is presented for constitutive hypoxemia within the carcinogenic tissue through analysis of the hemoglobin absorption spectra and distribution. Morphometric readouts obtained with optoacoustic mesoscopy have been verified with high-resolution ultramicroscopic studies. The findings described herein greatly extend the applications of optoacoustic mesoscopy toward structural and multispectral functional measurements of the vascularization and hemodynamics within solid tumors in vivo and are of major relevance to basic and preclinical oncological studies in small animal models.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Photoacoustic Tomography; Blood-flow; Angiogenesis; Neovascularization; Microenvironment; Visualization; Principles; Mesoscopy; Diseases; Growth
ISSN (print) / ISBN 1522-8002
e-ISSN 1476-5586
Zeitschrift Neoplasia : An International Journal for Oncology Research
Quellenangaben Band: 18, Heft: 8, Seiten: 459-467 Artikelnummer: , Supplement: ,
Verlag Neoplasia Press
Verlagsort New York
Begutachtungsstatus