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Wicker, T.* ; Yu, Y.* ; Haberer, G. ; Mayer, K.F.X. ; Marri, P.R.* ; Rounsley, S.* ; Chen, M.* ; Zuccolo, A.* ; Panaud, O.* ; Wing, R.A.* ; Roffler, S.*

DNA transposon activity is associated with increased mutation rates in genes of rice and other grasses.

Nat. Commun. 7:12790 (2016)
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Open Access Gold
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DNA (class 2) transposons are mobile genetic elements which move within their 'host' genome through excising and re-inserting elsewhere. Although the rice genome contains tens of thousands of such elements, their actual role in evolution is still unclear. Analysing over 650 transposon polymorphisms in the rice species Oryza sativa and Oryza glaberrima, we find that DNA repair following transposon excisions is associated with an increased number of mutations in the sequences neighbouring the transposon. Indeed, the 3,000 bp flanking the excised transposons can contain over 10 times more mutations than the genome-wide average. Since DNA transposons preferably insert near genes, this is correlated with increases in mutation rates in coding sequences and regulatory regions. Most importantly, we find this phenomenon also in maize, wheat and barley. Thus, these findings suggest that DNA transposon activity is a major evolutionary force in grasses which provide the basis of most food consumed by humankind.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Double-strand Break; Maize Domestication; Genome Sequence; Repair; Plants; Arabidopsis; Evolution; Diversity; Pathways; Elements
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Quellenangaben Volume: 7, Issue: , Pages: , Article Number: 12790 Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Reviewing status Peer reviewed