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Impact of islet architecture on β-cell heterogeneity, plasticity and function.

Nat. Rev. Endocrinol. 12, 695-709 (2016)
Publ. Version/Full Text Postprint DOI
Open Access Green
Although β-cell heterogeneity was discovered more than 50 years ago, the underlying principles have been explored only during the past decade. Islet-cell heterogeneity arises during pancreatic development and might reflect the existence of distinct populations of progenitor cells and the developmental pathways of endocrine cells. Heterogeneity can also be acquired in the postnatal period owing to β-cell plasticity or changes in islet architecture. Furthermore, β-cell neogenesis, replication and dedifferentiation represent alternative sources of β-cell heterogeneity. In addition to a physiological role, β-cell heterogeneity influences the development of diabetes mellitus and its response to treatment. Identifying phenotypic and functional markers to discriminate distinct β-cell subpopulations and the mechanisms underpinning their regulation is warranted to advance current knowledge of β-cell function and to design novel regenerative strategies that target subpopulations of β cells. In this context, the Wnt/planar cell polarity (PCP) effector molecule Flattop can distinguish two unique β-cell subpopulations with specific transcriptional signatures, functional properties and differential responses to environmental stimuli. In vivo targeting of these β-cell subpopulations might, therefore, represent an alternative strategy for the future treatment of diabetes mellitus.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Pancreatic B-cells; Plasma-membrane Domains; Adhesion Molecule Ncam; Insulin-secretion; Endocrine Pancreas; Gene-expression; In-vivo; Gap-junctions; Intercellular Differences; Glucose-transporter
ISSN (print) / ISBN 1759-5029
e-ISSN 1759-5037
Quellenangaben Volume: 12, Issue: 12, Pages: 695-709 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place New York, NY
Reviewing status Peer reviewed