PuSH - Publikationsserver des Helmholtz Zentrums München

Lehmann, J.* ; Vomacka, J.* ; Esser, K. ; Nodwell, M.* ; Kolbe, K.* ; Raemer, P.* ; Protzer, U. ; Reiling, N.* ; Sieber, S.A.*

Human lysosomal acid lipase inhibitor lalistat impairs Mycobacterium tuberculosis growth by targeting bacterial hydrolases.

MedChemComm 7, 1797-1801 (2016)
Verlagsversion Forschungsdaten DOI
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Lalistat inhibits growth of Mycobacterium tuberculosis in bacterial culture as well as in infected macrophages. Target identification by quantitative proteomics revealed a cluster of 20 hydrolytic proteins including members of the lipase family. Lipases are essential for M. tuberculosis fatty acid production and energy storage thus representing promising antibiotic targets.
Altmetric
Weitere Metriken?
Zusatzinfos bearbeiten [➜Einloggen]
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter 1,3-dipolar Cycloadditions; Pancreatic Lipase; Terminal Alkynes; In-vitro; Tetrahydrolipstatin; Metabolism; Susceptibility; Lipstatin; Pathogen; Dormancy
ISSN (print) / ISBN 2040-2511
e-ISSN 2040-2503
Zeitschrift MedChemComm
Quellenangaben Band: 7, Heft: 9, Seiten: 1797-1801 Artikelnummer: , Supplement: ,
Verlag Royal Society of Chemistry (RSC)
Verlagsort Cambridge
Begutachtungsstatus Peer reviewed