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Chuah, S.Y.* ; Attia, A.B.E.* ; Long, V.* ; Ho, C.J.* ; Malempati, P.* ; Fu, C.Y.* ; Ford, S.J.* ; Lee, J.S.* ; Tan, W.P.* ; Razansky, D. ; Olivo, M.* ; Thng, S.*

Structural and functional 3D mapping of skin tumours with non-invasive multispectral optoacoustic tomography.

Skin Res. Technol. 23, 221-226 (2017)
Open Access Green as soon as Postprint is submitted to ZB.
BACKGROUND: Recent advances in technology have enabled the development of various non-invasive skin imaging tools to aid real-time diagnosis of both benign and malignant skin tumours, minimizing the need for invasive skin biopsy. Multispectral optoacoustic tomography (MSOT) is a recently developed non-invasive imaging tool, which offers the unique capacity for high resolution three dimensional (3D) optical mapping of tissue by further delivering highly specific optical contrast from a depth of several millimetres to centimetres in living tissues. MSOT enables volumetric, spectroscopic differentiation of tissue, both in vivo and in real time, with and without the application of biomarker-specific probes, and is further able of providing spatial maps of skin chromophores, as well as underlying blood vasculature. METHODS: Three patients with suspicious skin tumours consented to have their lesions imaged with MSOT prior to excision. The histological findings and measurements were compared. RESULTS: We demonstrated the first in vivo clinical use of MSOT for 3D reconstruction of skin tumours in three patients with good histological correlation. CONCLUSION: Our findings confirm the potential benefit of the new imaging method in guiding surgical intervention to achieve a more precise excision with better clearance and lower relapse rates. It can also potentially help to shorten the duration of Mohs' micrographic surgery. Further large-scale studies are necessary to ensure correlation between MSOT and histology.
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Publication type Article: Journal article
Document type Scientific Article
Keywords 3d Mapping ; Multispectral Optoacoustic Tomography ; Histopathology ; Imaging ; Skin Tumours; Confocal Microscopy; Diagnosis; Cancer; Dermatology
ISSN (print) / ISBN 0909-752X
e-ISSN 1600-0846
Quellenangaben Volume: 23, Issue: 2, Pages: 221-226 Article Number: , Supplement: ,
Publisher Wiley
Publishing Place Oxford
Reviewing status Peer reviewed