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Regina, B.F.* ; Gladyshev, V.N.* ; Arner, E.S.J.* ; Berry, M.J.* ; Bruford, E.A.* ; Burk, R.F.* ; Carlson, B.A.* ; Castellano, S.* ; Chavatte, L.* ; Conrad, M. ; Copeland, P.R.* ; Diamond, A.M.* ; Driscoll, D.M.* ; Ferreiro, A.* ; Flohé, L.* ; Green, F.R.* ; Guigo, R.* ; Handy, D.E.* ; Hatfield, D.L.* ; Hesketh, J.* ; Hoffmann, P.R.* ; Holmgren, A.* ; Hondal, R.J.* ; Howard, M.T.* ; Huang, K.M.* ; Kim, H.Y.* ; Kim, I.Y.* ; Köhrle, J.* ; Krol, A.* ; Kryukov, G.V.* ; Lee, B.J.* ; Lee, B.C.* ; Lei, X.G.* ; Liu, Q.* ; Lescure, A.* ; Lobanov, A.V.* ; Loscalzo, J.* ; Maiorino, M.* ; Mariotti, M.* ; Prabhu, K.S.* ; Rayman, M.P.* ; Rozovsky, S.* ; Salinas, G.* ; Schmidt, E.E.* ; Schomburg, L.* ; Schweizer, U.* ; Simonović, M.* ; Sunde, R.A.* ; Tsuji, P.A.* ; Tweedie, S.* ; Ursini, F.F.* ; Whanger, P.D.* ; Zhang, Y.*

Selenoprotein gene nomenclature.

J. Biol. Chem. 291, 24036-24040 (2016)
Verlagsversion DOI
Free by publisher
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The human genome contains 25 genes coding for selenocysteine- containing proteins (selenoproteins). These proteins are involved in a variety of functions, most notably redox homeostasis. Selenoprotein enzymes with known functions are designated according to these functions: TXNRD1, TXNRD2, and TXNRD3 (thioredoxin reductases), GPX1, GPX2, GPX3, GPX4, and GPX6 (glutathione peroxidases), DIO1, DIO2, and DIO3 (iodothyronine deiodinases), MSRB1 (methionine sulfoxide reductase B1), and SEPHS2 (selenophosphate synthetase 2). Selenoproteins without known functions have traditionally been denoted by SEL or SEP symbols. However, these symbols are sometimes ambiguous and conflict with the approved nomenclature for several other genes. Therefore, there is a need to implement a rational and coherent nomenclature system for selenoprotein- encoding genes. Our solution is to use the root symbol SELENO followed by a letter. This nomenclature applies to SELENOF (selenoprotein F, the 15-kDa selenoprotein, SEP15), SELENOH (selenoprotein H, SELH, C11orf31), SELENOI (selenoprotein I, SELI, EPT1), SELENOK (selenoprotein K, SELK), SELENOM (selenoprotein M, SELM), SELENON (selenoprotein N, SEPN1, SELN), SELENOO (selenoprotein O, SELO), SELENOP (selenoprotein P, SeP, SEPP1, SELP), SELENOS (selenoprotein S, SELS, SEPS1, VIMP),SELENOT(selenoprotein T, SELT),SELENOV(selenoprotein V, SELV), andSELENOW(selenoprotein W, SELW, SEPW1). This system, approved by the HUGO Gene Nomenclature Committee, also resolves conflicting, missing, and ambiguous designations for selenoprotein genes and is applicable to selenoproteins across vertebrates.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter function; gene name; genomics; nomenclature; selenium; selenocysteine; selenoprotein; structure-function; Hydroperoxide Glutathione-peroxidase; Amino-acid-sequence; Thioredoxin Reductase; Rat-liver; Iodothyronine 5-deiodinase; Eukaryotic Selenoproteins; Selenium Metabolism; Containing Proteins; Messenger-rna; Selenocysteine
ISSN (print) / ISBN 0021-9258
e-ISSN 1083-351X
Quellenangaben Band: 291, Heft: 46, Seiten: 24036-24040 Artikelnummer: , Supplement: ,
Verlag American Society for Biochemistry and Molecular Biology
Verlagsort Bethesda
Begutachtungsstatus Peer reviewed