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Spiral volumetric optoacoustic tomography visualizes multi-scale dynamics in mice.

Light Sci. Appl. 6:e16247 (2017)
Verlagsversion Postprint DOI
Open Access Gold
Creative Commons Lizenzvertrag
Imaging dynamics at different temporal and spatial scales is essential for understanding the biological complexity of living organisms, disease state and progression. Optoacoustic imaging has been shown to offer exclusive applicability across multiple scales with excellent optical contrast and high resolution in deep-tissue observations. Yet, efficient visualization of multi-scale dynamics remained difficult with state-of-the-art systems due to inefficient trade-offs between image acquisition time and effective field of view. Herein, we introduce the spiral volumetric optoacoustic tomography technique that provides spectrally enriched high-resolution contrast across multiple spatiotemporal scales. experiments in mice demonstrate a wide range of dynamic imaging capabilities, from three-dimensional high-frame-rate visualization of moving organs and contrast agent kinetics in selected areas to whole-body longitudinal studies with unprecedented image quality. The newly introduced paradigm shift in imaging of multi-scale dynamics adds to the multifarious advantages provided by the optoacoustic technology for structural, functional and molecular imaging.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Multi-scale Dynamics ; Multi-spectral Imaging ; Optoacoustic Tomography ; Real-time Imaging ; Whole-body Imaging
ISSN (print) / ISBN 2047-7538
e-ISSN 2047-7538
Quellenangaben Band: 6, Heft: 4, Seiten: , Artikelnummer: e16247 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Begutachtungsstatus Peer reviewed