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Karrasch, S. ; Behr, J.* ; Huber, R.M.* ; Nowak, D.* ; EUMODIC Consortium (Peters, A. ; Holle, R. ; Schulz, H. ; Leidl, R. ; Meisinger, C. ; Strauch, K.) ; Peters, S.* ; Jörres, R.A.*

Heterogeneous pattern of differences in respiratory parameters between elderly with either good or poor FEV1.

BMC Pulm. Med. 18:27 (2018)
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Spirometric indices as well as other respiratory and functional parameters decline with age, but the link between the changes is not well studied. We assessed their relationship in elderly subjects with either good or poor spirometric parameters to reveal whether different domains of lung function show comparable differences between the two groups. Among subjects of the population-based KORA-Age cohort (n=935, 65-90y; 51% male) two groups were selected from either the lower (LED; n=51) or the upper (UED; n=72) end of the FEV1 distribution. All subjects did not have a history of lung disease and were non-smokers at the time of the study. Measurements included spirometry, body plethysmography, diffusing capacity for NO and CO, respiratory pump function and exhaled NO (FeNO). In addition, 6-minute walking distance as a functional overall measure, as well as telomere length of blood leukocytes and serum 8-hydroxydeoxyguanosine (8-OHdG) as potential markers of overall biological ageing and stress were determined. In the majority of parameters, LED subjects showed significantly impaired values compared to UED subjects. Differences in spirometric parameters, airway resistance and respiratory pump function ranged between 10% and more than 90% in terms of predicted values. In contrast, volume-related CO and NO diffusing capacity showed differences between groups of lower than 5%, while telomere length, 8-OHdG and FeNO were similar. This was reflected in the differences in functional age as derived from prediction equations. In elderly subjects without a history of lung disease the differences in lung-mechanical parameters of spirometry and body plethysmography were higher than those of gas exchange. Thus, the concept of a general functional “lung age” might be inadequate and specific terms such as “spirometric age” should be preferred.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Spirometry, lung age, aging, diffusing capacity, body plethysmography
e-ISSN 1471-2466
Quellenangaben Volume: 18, Issue: , Pages: , Article Number: 27 Supplement: ,
Publisher BioMed Central
Publishing Place London
Reviewing status Peer reviewed